Journal
FRONTIERS IN PLANT SCIENCE
Volume 4, Issue -, Pages -Publisher
FRONTIERS RESEARCH FOUNDATION
DOI: 10.3389/fpls.2013.00503
Keywords
lipid rafts; membrane microdomains; super-resolution; fluorescence; cell membranes
Categories
Funding
- Marie Curie Career Integration Grant [334303]
- National Health and Medical Research Council of Australia [1037320]
- Australian Research Council
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The lipid bilayer of model membranes, liposomes reconstituted from cell lipids, and plasma membrane vesicles and spheres can separate into two distinct liquid phases to yield lipid domains with liquid-ordered and liquid-disordered properties. These observations are the basis of the lipid raft hypothesis that postulates the existence of cholesterol-enriched ordered-phase lipid domains in cell membranes that could regulate protein mobility, localization and interaction. Here we review the evidence that nano-scaled lipid complexes and meso-scaled lipid domains exist in cell membranes and how new fluorescence microscopy techniques that overcome the diffraction limit provide new insights into lipid organization in cell membranes.
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