Journal
FRONTIERS IN MICROBIOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2018.02178
Keywords
adenovirus; genome; evolution; transcription factor; interactome
Categories
Funding
- National Institutes of Health [EY013124, EY021558, EY014104]
- Research to Prevent Blindness, Inc., New York, NY
- Falk Foundation
- Massachusetts Lions Eye Research Fund
- NATIONAL EYE INSTITUTE [R01EY021558, P30EY014104, R01EY013124] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P20GM103447] Funding Source: NIH RePORTER
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Human adenovirus (HAdV) infections cause disease world-wide. Whole genome sequencing has now distinguished 90 distinct genotypes in 7 species (A-G). Over half of these 90 HAdVs fall within species D, with essentially all of the HAdV-D whole genome sequences generated in the last decade. Herein, we describe recent new findings made possible by mining of this expanded genome database, and propose future directions to elucidate new functional elements and new functions for previously known viral components.
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