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Immune Evasion of Enteroviruses Under Innate Immune Monitoring

Journal

FRONTIERS IN MICROBIOLOGY
Volume 9, Issue -, Pages -

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2018.01866

Keywords

innate immunity; enterovirus; immune evasion; Picornaviridae; innate lymphoid cells (ILCs)

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Funding

  1. CAMS Initiative for Innovative Medicine [CAMS-I2M-1-019]
  2. State Project for Essential Drug Research and Development [2017ZX09307013-2, 2016ZX09101120-2]
  3. National Natural Science Foundation of China [31700931]
  4. Medical reserve talents of Yunnan Province Health and Family Planning [H-201620]
  5. Major science and technology special projects of Yunnan Province [2017ZF020, 2016ZF002, 2014HB066, 2017FB018]

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As a major component of immunological defense against a great variety of pathogens, innate immunity is capable of activating the adaptive immune system. Viruses are a type of pathogen that proliferate parasitically in cells and have multiple strategies to escape from host immune pressure. Here, we review recent studies of the strategies and mechanisms by which enteroviruses evade innate immune monitoring.

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