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Modulation of dendritic cell functions by viral IL-10 encoded by human cytomegalovirus

Journal

FRONTIERS IN MICROBIOLOGY
Volume 5, Issue -, Pages -

Publisher

FRONTIERS RESEARCH FOUNDATION
DOI: 10.3389/fmicb.2014.00337

Keywords

dendritic cells; cytomegalovirus; interleukin 10; immunomodulation; virus replication and latency

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Human cytomegalovirus (HCMV), a clinically important beta-herpesvirus, is a master of evasion and modulation of the host immune system, including inhibition of a number of dendritic cell (DC) functions. DCs play a central role in co-ordination of the immune response against pathogens and any disturbance of DCs functions can result in a cascade effect on a range of immune cells. Recently, the HCMV gene UL111A, which encodes viral homologs of human interleukin 10, has been identified as a strong suppressor of a number of DCs functions. In this mini review, we focus on HCMV-encoded viral IL-10-mediated inhibitory effects on DCs and implications for the development of an effective HCMV vaccine.

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