Journal
FRONTIERS IN MICROBIOLOGY
Volume 5, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2014.00126
Keywords
vpx; HIV-2; SIVsmm; SAMHD1; myeloid cells; HIV-1; restriction factor; interferon type 1
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Funding
- MRC [G1001081, G1000196] Funding Source: UKRI
- Medical Research Council [G1001081, G1000196] Funding Source: Medline
- Medical Research Council [G1001081, G1000196] Funding Source: researchfish
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Vpx is a protein encoded by members of the HIV-2/SIVsmm and SIVrcm/SIVmnd-2 lineages of primate lentiviruses, and is packaged into viral particles. Vpx plays a critical role during the early steps of the viral life cycle and has been shown to counteract SAMHD1, a restriction factor in myeloid and resting T cells. However, it is becoming evident that Vpx is a multifunctional protein in that SAMHD1 antagonism is likely not its sole role. This review summarizes the current knowledge on this X-traordinary protein.
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