Journal
FRONTIERS IN MICROBIOLOGY
Volume 3, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2012.00059
Keywords
KSHV; ORF57; mRNA export; mRNA stability
Categories
Funding
- Biotechnology and Biological Sciences Research Council
- Wellcome Trust
- Yorkshire Cancer Research
- Leverhulme Trust
- BBSRC Research Development Fellowship
- Biotechnology and Biological Sciences Research Council [BB/G022836/1] Funding Source: researchfish
- BBSRC [BB/G022836/1] Funding Source: UKRI
Ask authors/readers for more resources
Post-transcriptional events which regulate mRNA biogenesis are fundamental to the control of gene expression. A nascent mRNA is therefore steered through multimeric RNA protein complexes that mediate its capping, splicing, polyadenylation, nuclear export, and ultimately its translation. Kaposi's sarcoma-associated herpesvirus (KSHV) mRNA transport and accumulation protein, or ORF57, is a functionally conserved protein found in all herpesviruses which plays a pivotal role in enhancing viral gene expression at a post-transcriptional level. As such, ORF57 has been implicated in multiple steps of RNA biogenesis, including augmenting viral splicing, protecting viral RNAs from degradation to enhancing viral mRNA nuclear export and translation. In this review, we highlight the multiple roles of KSHV ORF57 in regulating the post-transcriptional events which are fundamental to the control of virus gene expression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available