Journal
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
Volume 3, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2013.00028
Keywords
Brucella; TIR domain; Btp1/BtpA; TLR; DC; NF-kappa B
Categories
Funding
- Agence National Recherche (ANR BruTir)
- Centre National de la Recherche Scientifique
- Institut National de la Sante et de la Recherche Medicale
- Aix-Marseille Universite
- ARC convention from the French-Speaking Community of Belgium [08/13-015]
- ANR grant CELLPATH
- ERA-NET PathoGenoMics scheme
- ANPCyT PICT [2011-0253, 2011-1485]
- ANR BruTir
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Several bacterial pathogens have TIR domain containing proteins that contribute to their pathogenesis. We identified a second TIR-containing protein in Brucella spp. that we have designated BtpB. We show it is a potent inhibitor of TLR signaling, probably via MyD88. BtpB is a novel Brucella effector that is translocated into host cells and interferes with activation of dendritic cells. In vivo mouse studies revealed that BtpB is contributing to virulence and control of local inflammatory responses with relevance in the establishment of chronic brucellosis. Together, our results show that BtpB is a novel Brucella effector that plays a major role in the modulation of host innate immune response during infection.
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