Journal
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
Volume 2, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2012.00059
Keywords
neutrophils; Leishmania; inflammation; immune response; sand fly; apoptosis; dendritic cells; macrophages
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Funding
- Intramural Research Program of the National Institutes of Health, National Institute of Allergy and Infectious Diseases
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Neutrophils are the first cells recruited to the dermal site of Leishrnania infection following injection by needle or sand fly bite. The role of neutrophils in either promoting or suppressing host immunity remains controversial. We discuss the events driving neutrophil recruitment, their interaction with the parasite and apoptotic fate, and the nature of their encounters with other innate cells. We suggest that the influence of the neutrophil response on infection outcome critically depends on the timing of their recruitment and the tissue environment in which it occurs.
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