Journal
ENTOMOLOGICAL RESEARCH
Volume 44, Issue 6, Pages 244-253Publisher
WILEY-BLACKWELL
DOI: 10.1111/1748-5967.12075
Keywords
anticancer activity; fractionation; hepatocellular carcinoma; hepatoprotection; Protaetia brevitarsis
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Funding
- Rural Development Administration of Korea [PJ008969]
- Ministry for Food, Agriculture, Forestry, and Fisheries of Korea [311006-3]
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Protaetia brevitarsis larvae have been used as a traditional medicine to treat various liver diseases. Freeze-dried powder and solvent partitioned fractions of Protaetia brevitarsis larvae, in this study, were examined for hepatoprotective and antitumor activities in vivo and in vitro. Oral administration of the powder reduced signs of acute and chronic liver injuries in diethylnitrosamine-induced hepatotoxic mouse model. Various cancer cell types, but not normal primary hepatocytes, were killed by the hexane, ethyl acetate and butanol fractions, which were partitioned from larval extracts. Apoptosis and autophagy were primarily induced in cancer cells by hexane and ethyl acetate fractions, respectively, and can be the cytotoxic mechanisms of the fractions. Further analyses of the insect fractions could lead to identification of novel bioactive substances that can be exploited as therapeutics for various human liver diseases.
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