Journal
ELIFE
Volume 3, Issue -, Pages -Publisher
eLIFE SCIENCES PUBL LTD
DOI: 10.7554/eLife.04577
Keywords
-
Categories
Funding
- Howard Hughes Medical Institute
- Gatsby Charitable Foundation Gatsby Initiative Fund in Brain Circuitry at Columbia University
- Swartz Foundation
- Bundesministerium fur Bildung und Forschung Bernstein Focus Neurobiology of Learning [01GQ0932]
- Max-Planck-Gesellschaft
- Deutsche Forschungsgemeinschaft [TA 552/5-1]
- Japan Society for the Promotion of Science MEXT/JSPS KAKENHI [25890003, 26120705, 26119503, 26250001]
- Naito Foundation
- Jane Coffin Childs Memorial Fund for Medical Research
- G Harold and Leila Y. Mathers Foundation
- Simons Foundation
- Grants-in-Aid for Scientific Research [25890003, 26120705, 26119503, 26250001] Funding Source: KAKEN
Ask authors/readers for more resources
We identified the neurons comprising the Drosophila mushroom body (MB), an associative center in invertebrate brains, and provide a comprehensive map describing their potential connections. Each of the 21 MB output neuron (MBON) types elaborates segregated dendritic arbors along the parallel axons of similar to 2000 Kenyon cells, forming 15 compartments that collectively tile the MB lobes. MBON axons project to five discrete neuropils outside of the MB and three MBON types form a feedforward network in the lobes. Each of the 20 dopaminergic neuron (DAN) types projects axons to one, or at most two, of the MBON compartments. Convergence of DAN axons on compartmentalized Kenyon cell-MBON synapses creates a highly ordered unit that can support learning to impose valence on sensory representations. The elucidation of the complement of neurons of the MB provides a comprehensive anatomical substrate from which one can infer a functional logic of associative olfactory learning and memory.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available