Journal
ELIFE
Volume 3, Issue -, Pages -Publisher
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.04433
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Funding
- Fundacao para a Ciencia e Tecnologia Portugal [SFRH/BD/33247/2007]
- Netherlands Organization for Scientific Research (VICI grant) [918.56.612, 820.02.004, 823.02.011, 854.10.005, 916.13.011]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/33247/2007] Funding Source: FCT
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Non-hematopoietic lymph node stromal cells shape immunity by inducing WIC-I-dependent deletion of self-reactive CD8(+) T cells and WIC-II-dependent anergy of CD4(+) T cells. Here, we show that WIC-II expression on lymph node stromal cells is additionally required for homeostatic maintenance of regulatory T cells (Tregs) and maintenance of immune quiescence. In the absence of WIC-II expression in lymph node transplants, i.e. on lymph node stromal cells, CD4(+) as well as CD8(+) T cells became activated, ultimately resulting in transplant rejection. WIC-II self-antigen presentation by lymph node stromal cells allowed the non-proliferative maintenance of antigen-specific Tregs and constrained antigen-specific immunity. Altogether, our results reveal a novel mechanism by which lymph node stromal cells regulate peripheral immunity.
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