Journal
ELIFE
Volume 3, Issue -, Pages -Publisher
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.03180
Keywords
CD28; Germinal center; T follicular helper cell; T helper 1 type cell; T follicular regulatory cell; infection
Categories
Funding
- Wellcome Trust [083650/Z/07/Z, 098051]
- NHMRC Overseas Biomedical Fellowship
- Lister Prize Fellowship
- National Institute of Health Research Cambridge Biomedical Research Centre
- BBSRC [BBS/E/B/000C0407, BBS/E/B/0000S042] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/B/000C0407, BBS/E/B/0000S042] Funding Source: researchfish
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The costimulatory molecule CD28 is essential for activation of helper T cells. Despite this critical role, it is not known whether CD28 has functions in maintaining T cell responses following activation. To determine the role for CD28 after T cell priming we generated a strain of mice where CD28 is removed from CD4(+) T cells after priming. We show that continued CD28 expression is important for effector CD4(+) T cells following infection; maintained CD28 is required for the expansion of T helper type 1 cells, and for the differentiation and maintenance of T follicular helper cells during viral infection. Persistent CD28 is also required for clearance of the bacterium Cilrobacter rodentium from the gastrointestinal tract. Together, this study demonstrates that CD28 persistence is required for helper T cell polarization in response to infection, describing a novel function for CD28 that is distinct from its role in T cell priming.
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