Journal
CURRENT RHEUMATOLOGY REPORTS
Volume 14, Issue 1, Pages 30-38Publisher
SPRINGER
DOI: 10.1007/s11926-011-0215-5
Keywords
Scleroderma; Fibrosis; Dendritic cells; Vascular; Skin; Kidney; Lung; Liver
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Funding
- NIAID NIH HHS [R01 AI079178] Funding Source: Medline
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Dendritic cells are professional antigen-presenting cells that are most studied for their function in mediating T-cell tolerance and T-cell activation. In addition, recent evidence indicates that dendritic cells can regulate the vasculature and function of fibroblast-type cells. The potential contribution of dendritic cells to scleroderma and fibrosis is not well-understood. In this article, we review recent studies as well as describe our own ongoing work that points toward a role for dendritic cells in scleroderma and fibrosis.
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