4.0 Article

The Impact of Psychological Stress on Wound Healing: Methods and Mechanisms

Journal

CRITICAL CARE NURSING CLINICS OF NORTH AMERICA
Volume 24, Issue 2, Pages 201-+

Publisher

W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ccell.2012.03.006

Keywords

Wound healing; Stress; Cytokine; Cortisol; Psychoneuroimmunology; Oxytocin

Categories

Funding

  1. NCATS NIH HHS [UL1 TR000090] Funding Source: Medline
  2. NCCIH NIH HHS [R21 AT003912, AT003912] Funding Source: Medline
  3. NCI NIH HHS [P30 CA016058, CA16058, CA131029, CA126857, R01 CA126857, R01 CA131029] Funding Source: Medline
  4. NCRR NIH HHS [UL1RR025755, UL1 RR025755] Funding Source: Medline
  5. NIA NIH HHS [AG029562, P01 AG016321, R01 AG029562] Funding Source: Medline
  6. NIDCR NIH HHS [P50 DE013749] Funding Source: Medline

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The Impact of Psychological Stress on Wound Healing: Methods and Mechanisms 201 Jean-Philippe Gouin and Janice K. Kiecolt-Glaser Converging and replicated evidence indicates that psychological stress can modulate wound-healing processes. This article reviews the methods and findings of experimental models of wound healing. Psychological stress can have a substantial and clinically relevant impact on wound repair. Physiologic stress responses can directly influence wound-healing processes. Furthermore, psychological stress can indirectly modulate the repair process by promoting the adoption of health-damaging behaviors. Translational work is needed to develop innovative treatments able to attenuate stress-induced delays in wound healing.

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