Journal
CRITICAL CARE NURSING CLINICS OF NORTH AMERICA
Volume 23, Issue 1, Pages 67-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ccell.2010.12.004
Keywords
Microcirculation; Sepsis; Severe sepsis; Septic shock; Organ failure
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This article discusses the role of microcirculatory dysfunction in the pathophysiology of sepsis, reviewing the role of the endothelium in modulating microcirculatory flow, discussing the function of nitric oxide in mediating microcirculatory blood flow, and outlining means of evaluating microcirculatory function in septic patients. Finally, potential novel therapies and challenges in treating microcirculatory dysfunction in septic patients are discussed.
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