4.2 Article

Prolonged Nitric Oxide Exposure Enhances Anoikis Resistance and Migration through Epithelial-Mesenchymal Transition and Caveolin-1 Upregulation

Journal

BIOMED RESEARCH INTERNATIONAL
Volume 2014, Issue -, Pages -

Publisher

HINDAWI LTD
DOI: 10.1155/2014/941359

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Funding

  1. Ratchadaphiseksompot Endowment Fund, Chulalongkorn University [RES560530132-HR]
  2. Higher Education Research Promotion and National Research University Project of Thailand, Office of the Higher Education Commission

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Nitric oxide (NO) in tumor microenvironment may have a significant impact on metastatic behaviors of cancer. Noncytotoxic doses of NO enhanced anoikis resistance and migration in lung cancer H23 cells via an increase in lamellipodia, epithelial-mesenchymal transition (EMT) markers including vimentin and snail, and caveolin-1 (Cav-1). However, the induction of EMT was found in Cav-1-knock down cells treated with NO, suggesting that EMT was through Cav-1-independent pathway. These effects of NO were consistently observed in other lung cancer cells including H292 and H460 cells. These findings highlight the novel role of NO on EMT and metastatic behaviors of cancer cells.

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