Journal
BIOMED RESEARCH INTERNATIONAL
Volume 2014, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2014/906168
Keywords
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Funding
- National Science Council of the Republic of China [NSC 101-2311-B-009-005-MY3, NSC 102-2627-B-009-001]
- Ministry of Science and Technology [MOST 103-2221-E-038-013-MY2]
- UST-UCSD International Center of Excellence in Advanced Bioengineering - Ministry of Science and Technology I-RiCE Program [NSC-102-2911-I-009-101-]
- Veterans General Hospitals and University System of Taiwan (VGHUST) Joint Research Program [VGHUST103-G5-1-2]
- MOE ATU
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Eighty-one stool samples from Taiwanese were collected for analysis of the association between the gut flora and obesity. The supervised analysis showed that the most, abundant genera of bacteria in normal samples (from people with a body mass index (BMI) <= 24) were Bacteroides (27.7%), Prevotella (19.4%), Escherichia (12%), Phascolarctobacterium(3.9%), and Eubacterium (3.5%). The most abundant genera of bacteria in case samples (with a BMI >= 27) were Bacteroides (29%), Prevotella (21%), Escherichia (7.4%), Megamonas (5.1%), and Phascolarctobacterium (3.8%). A principal coordinate analysis (PCoA) demonstrated that normal samples were clustered more compactly than case samples. An unsupervised analysis demonstrated that bacterial communities in the gut were clustered into two main groups: N-like and OB-like groups. Remarkably, most normal samples (78%) were clustered in the N-like group, and most case samples (81%) were clustered in the OB-like group (Fisher's P value = 1.61E-07). The results showed that bacterial communities in the gut were highly associated with obesity. This is the first study in Taiwan to investigate the association between human gut flora and obesity, and the results provide new insights into the correlation of bacteria with the rising trend in obesity.
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