4.2 Article

Development of Dual Inhibitors against Alzheimer's Disease Using Fragment-Based QSAR and Molecular Docking

Related references

Note: Only part of the references are listed.
Article Chemistry, Medicinal

Quantitative structure and bioactivity relationship study on human acetylcholinesterase inhibitors

Aixia Yan et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)

Review Pharmacology & Pharmacy

The role of fragment-based and computational methods in polypharmacology

Giovanni Bottegoni et al.

DRUG DISCOVERY TODAY (2012)

Article Chemistry, Medicinal

Application of GQSAR for Scaffold Hopping and Lead Optimization in Multitarget Inhibitors

Subhash Ajmani et al.

MOLECULAR INFORMATICS (2012)

Review Pharmacology & Pharmacy

Exploring QSARs with Extended Topochemical Atom (ETA) Indices for Modeling Chemical and Drug Toxicity

Kunal Roy et al.

CURRENT PHARMACEUTICAL DESIGN (2010)

Review Chemistry, Medicinal

3D-QSAR in Drug Design - A Review

Jitender Verma et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2010)

Article Chemistry, Medicinal

Design and synthesis of 1,4-dihydropyridine derivatives as BACE-1 inhibitors

Soo-Jeong Choi et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)

Article Medicine, Research & Experimental

The enhancement of amyloid precursor protein and β-site amyloid cleavage enzyme 1 interaction: Amyloid-β production with aging

Lin Zou et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2010)

Review Biotechnology & Applied Microbiology

Protein aggregation diseases: pathogenicity and therapeutic perspectives

Adriano Aguzzi et al.

NATURE REVIEWS DRUG DISCOVERY (2010)

Article Biochemistry & Molecular Biology

Design, synthesis and evaluation of flavonoid derivatives as potent AChE inhibitors

Rong Sheng et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2009)

Article Chemistry, Medicinal

A novel QSAR model for predicting the inhibition of CXCR3 receptor by 4-N-aryl-[1,4] diazepane ureas

Antreas Afantitis et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2009)

Article Chemistry, Medicinal

Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds

Lorna Piazzi et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)

Review Clinical Neurology

BACE1 structure and function in health and Alzheimer's disease

Sarah L. Cole et al.

CURRENT ALZHEIMER RESEARCH (2008)

Review Chemistry, Medicinal

Multi-target-directed ligands to combat neurodegenerative diseases

Andrea Cavalli et al.

JOURNAL OF MEDICINAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Synthesis, anti-tuberculosis activity, and 3D-QSAR study of 4-(adamantan-1-yl)-2-substituted quinolines

Amit Nayyar et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2007)

Review Clinical Neurology

Therapeutic approaches to Alzheimer's disease

Hans-Wolfgang Klafki et al.

BRAIN (2006)

Review Biochemistry & Molecular Biology

Development of BACE1 inhibitors for Alzheimer's disease

Tao Guo et al.

CURRENT MEDICINAL CHEMISTRY (2006)

Article Oncology

Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo

Y Luo et al.

MOLECULAR CANCER THERAPEUTICS (2005)

Review Biochemistry & Molecular Biology

Twenty years of the Alzheimer's disease amyloid hypothesis: A genetic perspective

RE Tanzi et al.

Article Chemistry, Medicinal

Structure-based optimization of novel azepane derivatives as PKB inhibitors

CB Breitenlechner et al.

JOURNAL OF MEDICINAL CHEMISTRY (2004)

Article Chemistry, Multidisciplinary

An alignment-independent versatile structure descriptor for QSAR and QSPR based on the distribution of molecular features

K Baumann

JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES (2002)

Article Biochemical Research Methods

Beware of q(2)!

A Golbraikh et al.

JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2002)

Review Pharmacology & Pharmacy

Galantamine - A review of its use in Alzheimer's disease

LJ Scott et al.

DRUGS (2000)