Journal
BIOMED RESEARCH INTERNATIONAL
Volume 2013, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2013/902427
Keywords
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Funding
- Department of Health [HTD 432] Funding Source: Medline
- National Institute for Health Research [HTD 432] Funding Source: researchfish
- National Institutes of Health Research (NIHR) [HTD 432] Funding Source: National Institutes of Health Research (NIHR)
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In this study eight different phosphate-based glass compositions were prepared by melt-quenching: four in the (P2O5)(45)-(CaO)(16)-(Na2O)(15-x)-(MgO)(24)-(B2O3)(x) system and four in the system (P2O5)(50)-(CaO)(16)-(Na2O)(10-x)-(MgO)(24)-(B2O3)(x), where x = 0, 1, 5 and 10 mol%. The effect of B2O3 addition on the thermal properties, density, molar volume, dissolution rates, and cytocompatibility were studied for both glass systems. Addition of B2O3 increased the glass transition (T-g), crystallisation (T-c), melting (T-m), Liquidus (T-L) and dilatometric softening (T-d) temperature andmolar volume (V-m). Thethermal expansion coefficient (alpha) anddensity (rho) were seen to decrease. An assessment of the thermal stability of the glasses wasmade in terms of their processing window ( crystallisation onset, T-c,T-ons minus glass transition temperature, T-g), and an increase in the processing window was observed with increasing B2O3 content. Degradation studies of the glasses revealed that the rates decreased with increasing B2O3 content and a decrease in degradation rates was also observed as the P2O5 content reduced from 50 to 45 mol%. MG63 osteoblast-like cells cultured in direct contact with the glass samples for 14 days revealed comparative data to the positive control for the cell metabolic activity, proliferation, ALP activity, and morphology for glasses containing up to 5 mol% of B2O3.
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