Journal
BIOMED RESEARCH INTERNATIONAL
Volume 2013, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2013/870795
Keywords
-
Funding
- National Basic Research Program of China [2011CB510101, 2011CB510102]
- National Natural Science Foundation of China [31371335]
- Innovation Program of Shanghai Municipal Education Commission [12ZZ087]
- Leading Academic Discipline Project of Shanghai Municipal Education Commission Molecular Physiology
- First-class Discipline of Universities in Shanghai
- Foundation for The Excellent Youth [SHU10022]
Ask authors/readers for more resources
Observing what phenotype the overexpression or knockdown of gene can cause is the basic method of investigating gene functions. Many advanced biotechnologies, such as RNAi, were developed to study the gene phenotype. But there are still many limitations. Besides the time and cost, the knockdown of some gene may be lethal which makes the observation of other phenotypes impossible. Due to ethical and technological reasons, the knockdown of genes in complex species, such as mammal, is extremely difficult. Thus, we proposed a new sequence-based computational method called kNNA-based method for gene phenotypes prediction. Different to the traditional sequence-based computational method, our method regards the multiphenotype as a whole network which can rank the possible phenotypes associated with the query protein and shows a more comprehensive view of the protein's biological effects. According to the prediction result of yeast, we also find some more related features, including GO and KEGG information, which are making more contributions in identifying protein phenotypes. This method can be applied in gene phenotype prediction in other species.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available