Journal
BIOMATERIALS SCIENCE
Volume 2, Issue 2, Pages 167-175Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3bm60159e
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Funding
- Research Councils UK (RCUK)
- Royal Society
- BBSRC [BB/I002286/1]
- ISIS [BB/J014389/1]
- Advantage West Midlands (AWM)
- European Regional Development Fund (ERDF)
- Wellcome Trust
- University of Manchester Strategic Fund
- Biotechnology and Biological Sciences Research Council [BB/J014389/1, BB/I002847/1, BB/I002286/1] Funding Source: researchfish
- BBSRC [BB/I002847/1, BB/J014389/1] Funding Source: UKRI
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A water-soluble azide-functionalised chitosan was crosslinked with propiolic acid ester-functional poly(ethylene glycol) using copper-free click chemistry. The resultant hydrogel materials were formed within 5-60 min at 37 degrees C and resulted in mechanically robust materials with tuneable properties such as swelling, mechanical strength and degradation. Importantly, the hydrogels supported mesenchymal stem cell attachment and proliferation and were also non-toxic to encapsulated cells. As such these studies indicate that the hydrogels have potential to be used as injectable biomaterials for tissue engineering.
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