Journal
BIOMATERIALS SCIENCE
Volume 2, Issue 10, Pages 1332-1337Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4bm00156g
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Funding
- Ministry of Science and Technology of Taiwan [NSC 101-2628-M-019-001-MY3, NSC 102-2113-M-019-001-MY3, NSC 102-2627-M-019-001-MY3]
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Graphene oxide (GO) modified with 29-mer thrombin-binding-aptamer-conjugated gold nanoparticles (TBA(29)-Au NPs/GO) can synergistically inhibit the thrombin-mediated cleavage of fibrinogen to fibrin. To further improve anticoagulation efficiency in human plasma, TBA(29)-Au NPs/heparin/GO has been prepared from TBA(29)-Au NPs/GO and heparin that can also bind thrombin. The dose-dependence of thrombin clotting time (TCT) delay caused by TBA(29)-Au NPs/heparin/GO is 21.4, 17.0 and >100 times higher than that caused by the TBA(29)-Au NPs, TBA(29)-Au NPs/GO and commercially available drugs (heparin, argatroban, hirudin or warfarin), respectively.
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