Journal
BIOMATERIALS SCIENCE
Volume 1, Issue 9, Pages 912-917Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3bm60090d
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Funding
- Singapore National Research Foundation [NRF2009NRF-RF001-015]
- Singapore National Research Foundation CREATE program - Singapore Peking University Research Centre for a Sustainable Low-Carbon Future
- Centre of Excellence for Silicon Technologies (A*Star SERC) [112 351 0003]
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Mesoporous silica nanoparticles (MSNPs) are functionalized with 15-mer single-stranded DNA (ssDNA). After loading of doxorubicin, functionalized MSNPs are capped with 33-mer complementary ssDNA through the formation of double-stranded DNA. Encapsulated doxorubicin could be released by either thermal-triggered denaturization of the DNA capping chains or redox-induced disulfide bond cleavage. An in vitro study shows successful delivery of doxorubicin into HeLa cells.
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