Journal
ASIAN JOURNAL OF ORGANIC CHEMISTRY
Volume 3, Issue 4, Pages 433-436Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.201400004
Keywords
amino acids; aryl triflates; organocatalysis; phase-transfer catalysis; synthetic methods
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Funding
- JSPS
- MEXT (Japan)
- Grants-in-Aid for Scientific Research [24106716, 21000006, 26220803] Funding Source: KAKEN
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Highly enantioselective -arylation of -amino acid derivatives via nucleophilic aromatic substitution (SNAr) was achieved under phase-transfer conditions. Various kinds of -amino acids and aryl triflates containing a nitro group can be tolerated in this reaction to give ,-disubstituted -amino acids in good to high enantioselectivity. This reaction demonstrates a valuable method for the catalytic asymmetric synthesis of ,-disubstituted -amino acids containing an aromatic substituent.
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