4.5 Article

Visible-Light-Mediated Radical Aryldifluoroacetylation of N-Arylacrylamides to give Difluoroacetylated Oxindoles

Journal

ASIAN JOURNAL OF ORGANIC CHEMISTRY
Volume 3, Issue 12, Pages 1273-1276

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.201402199

Keywords

alkenes; aryldifluoroacetylation; oxindoles; photoredox; radical reactions

Funding

  1. National Natural Science Foundation of China [U1204205, 21202078, 21272110, 21363004]
  2. Program for Innovative Research Team (in Science and Technology) at the University of Henan Province [14IRTSTHN008]

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A simple and practical approach to oxindole derivatives via visible-light-photocatalyzed aryldifluoroacetylation of N-arylacrylamides with BrCF2CO2Et has been developed. This method provides convenient access to a variety of difluoroester-substituted oxindoles under mild conditions.

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