Journal
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
Volume 46, Issue -, Pages S147-S155Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/21691401.2018.1489822
Keywords
Nano-drug; drug effect; molecular mechanisms; proteomics
Categories
Funding
- National Natural Science Foundation of China [81500900, 21775031, 21503054]
- 'Strategic Priority Research Program' of Chinese Academy of Sciences [XDA09040300]
- Beijing Municipal Science and Technology Project [Z171100002017013]
- Beijing Talents Fund [2015000021223ZK36]
- Beijing Municipal Natural Science Foundation [L172035, 2172056]
- Key Research Program of the Chinese Academy of Sciences [KFZD-SW-210]
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The first nano-platform commercialized as a drug delivery system was a liposomal formulation. The application of liposome technology resolved the issues of paclitaxel (PTX) insolubility and eliminated the use of solvents causing toxic side-effects, which enabled to apply higher drug doses leading to an enhanced drug efficacy. The growth-inhibitory activity of liposome-encapsulated PTX was retained in vitro against a variety of tumor cell. To investigate the drug efficacy in the system biological level, quantitative proteomic analysis was employed to study the molecular mechanism of the anti-tumor effect of Lipusu((R)) (lip) compared with PTX on lung cancer cell A549. The functions of the differential expressed proteins were correlated to the negative effect to cell proliferation due to regulation of hippo pathway and prolonged cell cycle, as well as inhibitory cell exocytosis, which would cause the aggregation of free PTX. This investigation focused on the direct biological effect of lip to cancer cells. It was different from pharmaceutical issues about drug exposure, delivery and distribution which were widely investigated in other traditional studies. It was the first study about the drug effect of lip from the global molecular biological aspect.
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