Journal
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
Volume 44, Issue 1, Pages 27-40Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/21691401.2014.909822
Keywords
nanoparticles; nanostructured lipid carriers; solid lipid nanoparticles; targeted delivery
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Funding
- All India Council of Technical Engineering (AICTE)
- Department of Science and Technology [DST-FIST-SR/FST/LSI - 013/2010]
- University Grant Commission [UGC SAP - F.3_54/2011(SAP 2)]
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In the last few decades, various drug-delivery technologies have emerged and a fascinating part of this has been the development of nanoscale drug delivery devices. Nanoparticles (NPs) and other colloidal drug-delivery systems modify the kinetics, drug distribution in the body and release profile of an associated drug. Nanostructured lipid carriers (NLCs) have been reported to be an alternative system to emulsions, liposomes, microparticles, solid lipid nanoparticles (SLNs) and their polymeric counterparts due to their numerous advantages. This paper basically reviews the types of NLCs, mechanism of skin penetration, stability related issues along with their production techniques, characterisation and applications towards targeted drug delivery.
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