Electrochemical glucose biosensor based on nickel oxide nanoparticle-modified carbon paste electrode

In the present work, we designed an amperometric glucose biosensor based on nickel oxide nanoparticles (NiONPs)-modified carbon paste electrode. The biosensor was prepared by incorporation of glucose oxidase and NiONPs into a carbon paste matrix. It showed good analytical performances such as high sensitivity (367 mu A mmolL(-1)) and a wide linear response from 1.9 x 10(-3) mmolL(-1) to 15.0 mmolL(-1) with a limit of detection (0.11 mu molL(-1)). The biosensor was used for the determination of glucose in human serum samples. The results illustrate that NiONPs have enormous potential in the construction of biosensor for determination of glucose.