Journal
ACS INFECTIOUS DISEASES
Volume 1, Issue 11, Pages 512-522Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsinfecdis.5b00097
Keywords
Gram-negative resistance; permeability barrier; outer membrane; multidrug efflux
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Funding
- Department of the Defense, Defense Threat Reduction Agency
- National Institute of Health [AI052293]
- DOE/LANL-DR project
- Center of Nonlinear Studies at LANL
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Gram-negative bacteria are intrinsically resistant to many antibiotics. Species that have acquired multidrug resistance and cause infections that are effectively untreatable present a serious threat to public health. The problem is broadly recognized and tackled at both the fundamental and applied levels. This paper summarizes current advances in understanding the molecular bases of the low permeability barrier of Gram-negative pathogens, which is the major obstacle in discovery and development of antibiotics effective against such pathogens. Gaps in knowledge and specific strategies to break this barrier and to achieve potent activities against difficult Gram-negative bacteria are also discussed.
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