Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 1, Issue 12, Pages 1200-1205Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.5b00375
Keywords
rational design; immunology; self-assembly; vaccine; polyelectrolyte multilayer
Categories
Funding
- NSF [1351688]
- University of Maryland Division of Research (Tier 1)
- NIH [T32 CA154274, T32 AI089621]
- Alex's Lemonade Stand Foundation
- American Association of Pharmaceutical Scientists Foundation
- NSF Graduate Research Fellowship Program [DGE1322106]
- Damon Runyon Foundation
- Alliance for Cancer Gene Therapy
- Melanoma Research Alliance
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1351688] Funding Source: National Science Foundation
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New vaccine adjuvants that direct immune cells toward specific fates could support more potent and selective options for diseases spanning infection to cancer. However, the empirical nature of vaccines and the complexity of many formulations has hindered design of well-defined and easily characterized vaccines. We hypothesized that nanostructured capsules assembled entirely from polyionic immune signals might support a platform for simple, modular vaccines. These immune-polyelectrolyte (iPEM) capsules offer a high signal density, selectively expand T cells in mice, and drive functional responses during tumor challenge. iPEMs incorporating clinically relevant antigens could improve vaccine definition and support more programmable control over immunity.
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