Journal
ADVANCED OPTICAL MATERIALS
Volume 6, Issue 20, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adom.201800690
Keywords
biological imaging; bright SWIR luminescence; core-shell nanocrystals; Er3+-sensitized
Categories
Funding
- National Natural Science Foundation of China [51672061, 61525503, 61620106016]
- Fundamental Research Funds for the Central Universities, China [HIT.BRETIV.201503]
Ask authors/readers for more resources
The 1500-1700 nm spectral range in short wave infrared (SWIR) region allows for biological imaging with large imaging depth, high contrast and resolution. However, very few SWIR imaging probes exist, and rarely reported probes (e.g., rare-earth-based ones with excitation at 980 nm) are often associated with biological heating effect. Here, a class of erbium (Er3+)-sensitized core-shell nanocrystals of NaErF4:Yb3+@NaLuF4, which emit efficient SWIR luminescence peaked at 1525 nm under 808 nm excitation, without producing any local heating, is described. The inert shell inhibits concentration-dependent quenching and allows for an enriched incorporation of 100% Er3+ into the core, yielding about approximate to 650-fold higher SWIR luminescence than parent core nanocrystals. Importantly, an appropriate doping of ytterbium (Yb3+) (optimized concentration, 20%) into the core is shown to further enhance SWIR luminescence (by twofold), endowing the nanocrystals with a high quantum yield of 11%. This Yb3+-mediated enhancement is possibly due to the suppression of upconverting pathways and the formation of energy trapping centers that prevent the energy migration to intrinsic lattice defects. These bright SWIR core/shell nanocrystals allow high contrast in vitro imaging of HeLa cells and in vivo through-skull imaging of blood vasculature in the mouse brain.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available