Journal
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
Volume 11, Issue -, Pages 1187-1193Publisher
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.11.133
Keywords
endophytic fungus; depsidone; alpha-glucosidase inhibitory activity; isoindolinone; Meyerozyma guilliermondii
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Funding
- National Natural Science Foundation of China [21472251, 41276146]
- Science & Technology Plan Project of Guangdong Province of China [2013B021100011]
- Special Financial Fund of Innovative Development of Marine Economic Demonstration Project [GD2012-D01-001]
- China's Marine Commonwealth Research Project [201305017]
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Three new depsidones, botryorhodines E-G (1-3), and two new isoindolinones, meyeroguillines A and B (7 and 9), along with five known compounds were isolated from an endophytic fungus Meyerozyma guilliermondii, derived from the mangrove plant Kandelia obovata. Their structures were elucidated by 1D and 2D NMR spectroscopy and high resolution mass spectrometry (HREIMS). Compounds 1-6 exhibited strong alpha-glucosidase inhibitory activity with IC50 values ranging from 2.1 to 13.3 mu M. Moreover, kinetic studies of compounds 2 and 6 showed that both of them were noncompetitive inhibitors of alpha-glucosidase.
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