4.5 Review

Enantioselective additions of copper acetylides to cyclic iminium and oxocarbenium ions

Journal

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
Volume 11, Issue -, Pages 2696-2706

Publisher

BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.11.290

Keywords

catalysis; copper; enantioselectivity; iminium ion; oxocarbenium ion

Funding

  1. National Science Foundation [CAREER CHE 1151364]
  2. Direct For Mathematical & Physical Scien
  3. Division Of Chemistry [1151364] Funding Source: National Science Foundation

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The development of enantioselective, copper-catalyzed alkynylations of cyclic iminium and oxocarbenium ions is reviewed. The use of chiral copper-based catalysts has enabled high yields and enantioselectivites in the formation of nitrogen- and oxygen-containing heterocycles with alpha-stereogenic centers. This review highlights both the accomplishments and the future work needed in this important area.

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