Journal
ADVANCES IN MATERIALS SCIENCE AND ENGINEERING
Volume 2012, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2012/185905
Keywords
-
Categories
Funding
- National Nature Science Foundation of China [30970714]
- Nature Science Foundation of Jiangsu Province [BK2010252]
- College Natural Science Research Project of Jiangsu Province [12KJA430003]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
Ask authors/readers for more resources
Silk fibroin has a unique and useful combination of properties, including good biocompatibility and excellent mechanical performance. These features provided early clues to the utility of regenerated silk fibroin as a scaffold/matrix for tissue engineering. The silk fibroin scaffolds used for tissue engineering should degrade at a rate that matches the tissue growth rate. The relationship between secondary structure and biodegradation behavior of silk fibroin scaffolds was investigated in this study. Scaffolds with different secondary structure were prepared by controlling the freezing temperature and by treatment with carbodiimide or ethanol. The quantitative proportions of each secondary structure were obtained by Fourier transform infrared spectroscopy (FTIR), and each sample was then degraded in vitro with collagenase IA for 18 days. The results show that a high content of beta-sheet structure leads to a low degradation rate. The random coil region in the silk fibroin material is degraded, whereas the crystal region remains stable and the amount of beta-sheet structure increases during incubation. The results demonstrate that it is possible to control the degradation rate of a silk fibroin scaffold by controlling the content of beta-sheet structure.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available