Journal
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
Volume 6, Issue 11, Pages 15064-15071Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acssuschemeng.8b03540
Keywords
ROS generation; Bacteria killing; Aggregation-induced emission (AIE); Photodynamic therapy (PDT); Fluorescence imaging
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Funding
- National Natural Science Foundation of China [21764012]
- Key Laboratory of Eco-Environment-Related Polymer Materials (Northwest Normal University)
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The newly emerged pathogenic bacteria leads to the bactericides generations one by one, which is definitely a long-term and costly process. For the small organic molecule used as antibacterial materials, photostability, biomembrane penetrating ability, and long-term antibacterial ability still are questionable. In this work, we synthesized the multiple-cation charged aggregation-induced emission (AIE)-active polymer 1,2-diphenyl-1,2-bis(4-(pyridin-4-yl)phenyl) ethane-1,8-dibromooctane (DBPE-DBO). Due to the incorporating the dark toxicity from positively charged polymers, and the photo-toxicity from generation of singlet oxygen, as well as AIE-active fluorescence performance, DBPE-DBO could be employed as an efficient bacteria targeting, imaging, and killing materials. Interestingly, DBPE-DBO was less toxic to the normal mammalian cells, which leads us to verify that DBPE-DBO could be used as a very cell-membrane permeable nucleus imaging probes. Thus, our research results may provide a new concept for the designing advanced biomaterials with versatile antibacterial properties and cell imaging ability.
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