Journal
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
Volume 2, Issue 7, Pages 1581-1591Publisher
AMER CHEMICAL SOC
DOI: 10.1021/sc500102h
Keywords
Exposure-response; Multi-source data; Stochastic kriging; Gaussian process; Nanotoxicoiogy
Categories
Funding
- National Science Foundation [CBET-1065931]
- National Institute of Environmental Health Sciences [1RC2E5018742-01]
- Directorate For Engineering [1065931] Funding Source: National Science Foundation
- Div Of Chem, Bioeng, Env, & Transp Sys [1065931] Funding Source: National Science Foundation
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One of the most fundamental steps in risk assessment is to quantify the exposure-response relationship for the material/chemical of interest. This work develops a new statistical method, referred to as SKQ (stochastic kriging with qualitative factors), to synergistically model exposure-response data, which often arise from multiple sources (e.g., laboratories, animal providers, and shapes of nanomaterials) in toxicology studies. Compared to the existing methods, SKQ has several distinct features. First, SKQ integrates data across multiple sources and allows for the derivation of more accurate information from limited data. Second, SKQ is highly flexible and able to model practically any continuous response surfaces (e.g., dose-time-response surface). Third, SKQ is able to accommodate variance heterogeneity across experimental conditions and to provide valid statistical inference (i.e., quantify uncertainties of the model estimates). Through empirical studies, we have demonstrated SKQ's ability to efficiently model exposure-response surfaces by pooling information across multiple data sources. SKQ fits into the mosaic of efficient decision-making methods for assessing the risk of a tremendously large variety of nanomaterials and helps to alleviate safety concerns regarding the enormous amount of new nanomaterials.
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