Journal
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
Volume 1, Issue 6, Pages 566-569Publisher
AMER CHEMICAL SOC
DOI: 10.1021/sc400058r
Keywords
PEG resin; Solid phase peptide synthesis; Peptide amide; Aqueous; N-carboxyanhydride; Microwave irradiation; Unprotected amino acids
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Funding
- Fondazione Umberto Veronesi, Milano/Roma, MIUR (PRIN)
- Italian Minister for Foreign Affairs
- Fondazione per la Ricerca sulla Fibrosi Cistica, Verona (FFC) [11/2011]
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The increasing need for large quantities of biologically active peptides for the market strongly raised the problem of the environmental sustainability of their synthesis. In this respect, we describe herein a solid phase procedure in water, using PEG peptide amide resins and NCAs under controlled conditions. This procedure afforded with reasonable yield and purity a short peptide amide, Without the need of coupling reagents or protecting groups.
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