4.5 Article

Visible-light-induced bromoetherification of alkenols for the synthesis of β-bromotetrahydrofurans and -tetrahydropyrans

Journal

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
Volume 11, Issue -, Pages 1-6

Publisher

BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.11.5

Keywords

alkenols; bromoetherification; photoredox catalysis; visible light

Funding

  1. China NSFC [21272047, 21372055, 21472030]
  2. SKLUWRE [2014DX01]
  3. Fundamental Research Funds for the Central Universities [HIT.BRETIV.201310]
  4. HLJNSF [B201406]

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A visible-light-induced photoredox-catalyzed bromoetherification of alkenols is described. This approach, with CBr4 as the bromine source through generation of bromine in situ, provides a mild and operationally simple access to the synthesis of beta-bromotetrahydrofurans and -tetrahydropyrans with high efficiency and regioselectivity.

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