Journal
WILEY INTERDISCIPLINARY REVIEWS-RNA
Volume 4, Issue 1, Pages 35-48Publisher
WILEY-BLACKWELL
DOI: 10.1002/wrna.1144
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Funding
- National Institutes of Health [R01-GM087543, R01 GM084065]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM084065, R01GM087543] Funding Source: NIH RePORTER
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Following synthesis, tRNAs are peppered by numerous chemical modifications which may differentially affect a tRNA's structure and function. Although modifications affecting the business ends of a tRNA are predictably important for cell viability, a majority of modifications play more subtle structural roles that can affect tRNA stability and folding. The current trend is that modifications act in concert and it is in the context of the specific sequence of a given tRNA that they impart their differing effects. Recent developments in the modification field have highlighted the diversity of modifications in tRNA. From these, the combinatorial nature of modifications in explaining previously described phenotypes derived from their absence has emerged as a growing theme. WIREs RNA 2013, 4:3548. doi: 10.1002/wrna.1144 For further resources related to this article, please visit the WIREs website.
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