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G-quadruplexes in RNA biology

Journal

WILEY INTERDISCIPLINARY REVIEWS-RNA
Volume 3, Issue 4, Pages 495-507

Publisher

WILEY-BLACKWELL
DOI: 10.1002/wrna.1113

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Funding

  1. INSERM
  2. FRM (Equipe FRM, soutenue par la Fondation Recherche Medicale)
  3. Fondation RITC (Recherche et Innovation Therapeutique en Cancerologie)
  4. Fondation Jerome Lejeune

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G-quadruplexes are noncanonical structures formed by G-rich DNA and RNA sequences that fold into a four-stranded conformation. Experimental studies and computational predictions show that RNA G-quadruplexes are present in transcripts associated with telomeres, in noncoding sequences of primary transcripts and within mature transcripts. RNA G-quadruplexes at these specific locations play important roles in key cellular functions, including telomere homeostasis and gene expression. Indeed, RNA G-quadruplexes appear as important regulators of pre-mRNA processing (splicing and polyadenylation), RNA turnover, mRNA targeting and translation. The regulatory mechanisms controlled by RNA G-quadruplexes involve the binding of protein factors that modulate G-quadruplex conformation and/or serve as a bridge to recruit additional protein regulators. In this review, we summarize the current knowledge on the role of G-quadruplexes in RNA biology with particular emphasis on the molecular mechanisms underlying their specific function in RNA metabolism occurring in physiological or pathological conditions. WIREs RNA 2012, 3:495507. doi: 10.1002/wrna.1113 For further resources related to this article, please visit the .

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