Journal
WILEY INTERDISCIPLINARY REVIEWS-RNA
Volume 3, Issue 5, Pages 675-695Publisher
WILEY
DOI: 10.1002/wrna.1128
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Funding
- Australian Research Council
- National Health and Medical Research Council of Australia
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The human mitochondrial transcriptome, although produced from a small and compact genome, has revealed surprising complexity in its composition and regulation. Wide variation between individual tRNAs, mRNAs, and rRNAs indicate the importance of post-transcriptional processing, maturation, and degradation mechanisms in the regulation of mitochondrial gene expression. RNA-binding proteins play essential roles in controlling the mitochondrial transcriptome from its synthesis to its destruction and have evolved unique features to complement the unusual features of mitochondrial RNAs. Recent studies have shown how changes in mitochondrial RNAs and their binding proteins can have significant effects on human health. This opens new avenues for investigation of mitochondrial RNA-binding proteins and the mechanisms by which they regulate mitochondrial gene expression. WIREs RNA 2012 doi: 10.1002/wrna.1128 For further resources related to this article, please visit the WIREs website.
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