Journal
TRANSPLANTATION REVIEWS
Volume 26, Issue 1, Pages 27-29Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.trre.2011.10.003
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The use of mammalian target of rapamycin inhibitor (mTOR-I) after kidney transplantation has been associated with a higher incidence of proteinuria compared with calcineurin inhibitors (CNIs). This review will focus on mTOR-I associated proteinuria in different settings after kidney transplantation: de novo mTOR-I treatment in combination with CNI, de novo mTOR-I containing and CNI-free treatment, early conversion from a CNI-based regimen to an mTOR-I based regimen, and late conversion. Some possible mechanisms of mTOR-I-induced proteinuria will also be reviewed. (C) 2012 Published by Elsevier Inc.
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