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Hemorrhage Rates and Risk Factors in the Natural History Course of Brain Arteriovenous Malformations

Journal

TRANSLATIONAL STROKE RESEARCH
Volume 5, Issue 5, Pages 538-542

Publisher

SPRINGER
DOI: 10.1007/s12975-014-0351-0

Keywords

Arteriovenous malformation; Epidemiology; Intracerebral hemorrhage; Natural history; Risk factor; Survival; Treatment

Funding

  1. National Institute of Neurological Disorders and Stroke (NINDS) [R01 NS034949, P01 NS044155]

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Brain arteriovenous malformations (AVMs) are abnormal connections of arteries and veins, resulting in arteriovenous shunting of blood. Primary medical therapy is lacking; treatment options include surgery, radiosurgery, and embolization, often in combination. Judicious selection of AVM patients for treatment requires balancing risk of treatment complications against the risk of hemorrhage in the natural history course. This review focuses on the epidemiology, hemorrhage risk, and factors influencing risk of hemorrhage in the untreated natural course associated with sporadic brain AVM.

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