Journal
TRANSLATIONAL STROKE RESEARCH
Volume 4, Issue 2, Pages 201-207Publisher
SPRINGER
DOI: 10.1007/s12975-012-0217-2
Keywords
Gender difference; Asphyxia; Neonate; Neuroprotection; Nitric oxide; Microglia
Categories
Funding
- Swedish Research Council
- Swedish Childhood Cancer Foundation (Barncancerfonden)
- governmental grants from Agreement concerning research and education of doctors (ALF)
- Swedish Medical Society (SLS)
- Sten A. Olsson's Foundation
- National Natural Science Foundation of China [31271152]
- Wilhelm and Martina Lundgren Foundation
- Frimurare Barnhus Foundation
- Third Phase 211 project of Zhengzhou University
- Health Department of Henan Province,
- Edit Jacobson's Donation Foundation
- Kungl. Vetenskaps- och Vitterhetssamhallet i Goteborg
- Gothenburg Medical Society
- Swedish Medical Society
- Aina Wallstrom's and Mary-Ann Sjoblom's Foundation
- Ulla and Rune Amlov Foundation
- AFA Insurance
- Swedish Society of Medicine
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It was recently discovered that while under normal conditions inhaled nitric oxide (iNO) does not affect cerebral blood flow, it selectively dilates arterioles in the ischemic penumbra during experimental cerebral ischemia, thereby increasing collateral blood flow and reducing ischemic brain damage. The mechanism was verified in multiple models, but only in male animals. Our aim was to evaluate the effects of iNO on brain injury in neonatal males and females. Nine-day-old mice were subjected to unilateral hypoxia-ischemia (HI), using 10 % oxygen balanced with nitrogen, with or without 50 ppm NO. Brain injury 72 h after HI was reduced by iNO as judged by percentage of injury (-21.7 %), atrophy (-23.7 %), and total pathological score (-29 %). The injury was significantly reduced in males (-32.4 %, p < 0.05) but not in females (-7.1 %, n.s.). Neither the numbers nor the proliferation rates of neural stem cells in the dentate gyrus were affected by iNO. In summary, intraischemic iNO reduced neonatal HI brain injury in a gender-related manner.
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