Journal
TOXINS
Volume 3, Issue 3, Pages 260-293Publisher
MDPI
DOI: 10.3390/toxins3030260
Keywords
nAChR; P2X; GABA; Glycine; Serotonin; NMDA; AMPA; Kainate
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Ligand-gated ion channels (LGIC) play a central role in inter-cellular communication. This key function has two consequences: (i) these receptor channels are major targets for drug discovery because of their potential involvement in numerous human brain diseases; (ii) they are often found to be the target of plant and animal toxins. Together this makes toxin/receptor interactions important to drug discovery projects. Therefore, toxins acting on LGIC are presented and their current/potential therapeutic uses highlighted.
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