Journal
TOXINS
Volume 2, Issue 1, Pages 128-162Publisher
MDPI AG
DOI: 10.3390/toxins2010128
Keywords
curcumin; cancer; inflammation; cell proliferation; genomic
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Funding
- Televie grants (Fonds National de la Recherche Scientifique, Belgium)
- Recherche Cancer et Sang foundation
- Recherches Scientifiques Luxembourg asbl
- Een Haerz fir Kriibskrank Kanner association
- European Union (ITN RedCat) [215009]
- European Union
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As cancer is a multifactor disease, it may require treatment with compounds able to target multiple intracellular components. We summarize here how curcumin is able to modulate many components of intracellular signaling pathways implicated in inflammation, cell proliferation and invasion and to induce genetic modulations eventually leading to tumor cell death. Clinical applications of this natural compound were initially limited by its low solubility and bioavailability in both plasma and tissues but combination with adjuvant and delivery vehicles was reported to largely improve bio-availability of curcumin. Moreover, curcumin was reported to act in synergism with several natural compounds or synthetic agents commonly used in chemotherapy. Based on this, curcumin could thus be considered as a good candidate for cancer prevention and treatment when used alone or in combination with other conventional treatments.
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