Journal
TOXINS
Volume 2, Issue 4, Pages 428-452Publisher
MDPI
DOI: 10.3390/toxins2040428
Keywords
toxins; leukocytes; signal transduction
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Leukocytes are a heterogeneous group of cells that display differences in anatomic localization, cell surface phenotype, and function. The different subtypes include e. g., granulocytes, monocytes, dendritic cells, T cells, B cells and NK cells. These different cell types represent the cellular component of innate and adaptive immunity. Using certain toxins such as pertussis toxin, cholera toxin or clostridium difficile toxin, the regulatory functions of G alpha i, G alpha s and small GTPases of the Rho family in leukocytes have been reported. A summary of these reports is discussed in this review.
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