Journal
TOXINS
Volume 1, Issue 2, Pages 123-133Publisher
MDPI AG
DOI: 10.3390/toxins1020123
Keywords
bacterial protein toxin; Vibrio; MARTX; VgrG; actin; ACD
Categories
Funding
- Burroughs Wellcome Fund
- National Institutes of Health [AI051490, AI072461]
Ask authors/readers for more resources
Actin crosslinking toxins produced by Gram-negative bacteria represent a small but unique class of bacterial protein toxins. For each of these toxins, a discrete actin crosslinking domain (ACD) that is a distant member of the ATP-dependent glutamine synthetase family of protein ligases is translocated to the eukaryotic cell cytosol. This domain then incorporates a glutamate-lysine crosslink between actin monomers, resulting in destruction of the actin cytoskeleton. Recent studies argue that the function of these toxins during infection is not destruction of epithelial layers, but rather may specifically target phagocytic cells to promote survival of bacteria after the onset of innate immune defenses. This review will summarize key experiments performed over the past 10 years to reveal the function of these toxins.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available