Journal
TOXINS
Volume 1, Issue 2, Pages 74-99Publisher
MDPI
DOI: 10.3390/toxins1020074
Keywords
Aspergillus; cyclopiazonic acid; gene cluster; non-ribosomal peptide synthase
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Cyclopiazonic acid (CPA) is an indole-tetramic acid neurotoxin produced by some of the same strains of A. flavus that produce aflatoxins and by some Aspergillus oryzae strains. Despite its discovery 40 years ago, few reviews of its toxicity and biosynthesis have been reported. This review examines what is currently known about the toxicity of CPA to animals and humans, both by itself or in combination with other mycotoxins. The review also discusses CPA biosynthesis and the genetic diversity of CPA production in A. flavus/oryzae populations.
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