Journal
STEM CELLS TRANSLATIONAL MEDICINE
Volume 3, Issue 8, Pages 942-948Publisher
WILEY
DOI: 10.5966/sctm.2014-0020
Keywords
Breast cancer stem cells; Epithelial-mesenchymal transition; Metastasis; Tumor dormancy
Categories
Funding
- Susan G. Komen for the Cure [CCR12224440]
- New York State Stem Cell Science (NYSTEM) [C028109]
- Gottesman Institute for Stem Cell and Regenerative Medicine Research at Albert Einstein College of Medicine
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Accumulating evidence has shown that cancer stem cells (CSCs), the cancer cells that have long-term proliferative potential and the ability to regenerate tumors with phenotypically heterogeneous cell types, are important mediators of tumor metastasis and cancer relapse. In breast cancer, these cells often possess attributes of cells that have undergone an epithelial-mesenchymal transition (EMT). Signaling networks mediated by microRNAs and EMT-inducing transcription factors connect the EMT program with the core stem cell regulatory machineries. These signaling networks are also regulated by extrinsic niche signals that induce and maintain CSCs, contributing to metastatic colonization and promoting the reactivation of dormant tumor cells. Targeting these CSC pathways is likely to improve the efficacy of conventional chemo- and radiotherapies.
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